Microenvironment and related genes predict outcomes of patients with cervical cancer: evidence from TCGA and bioinformatic analysis

Cervical cancer (CESC) is one of the most common cancers and affects the female genital tract. Consistent HPV infection status has been determined to be a vital cause of tumorigenesis. HPV infection may induce changes to the immune system and limit the host’s immune response. Immunotherapy is therefore essential to improving the overall survival of both locally advanced and recurrent CESC patients. Using 304 relevant samples from TCGA, we assessed immune cell function in CESC patients to better understand the status of both tumor micro-environment cells and immune cells in CESC. Functional enrichment analysis, pathway enrichment analysis, and PPI network construction were performed to explore the differentially expressed genes (DEGs). The analysis identified 425 DEGs, which included 295 up-regulated genes and 130 down-regulated genes. We established that upregulation of CCL5 was correlated with significantly better survival, meaning that CCL5 expression could serve as a novel prognostic biomarker for CESC patients. We further focused on CCL5 as a hub gene in CESC, as it had significant correlations with increased numbers of several types of immune cells. Cell-type fractions of M1 macrophages were significantly higher in the high-immune-scores group, which was associated with better overall survival. Finally, we concluded that CCL5 is a promising prognostic biomarker for CESC, as well as a novel chemotherapeutic target.     

基于强化学习的电力市场信息披露程度对市场成员交易行为影响研究

基于信息披露的主体框架，分析披露体系中具体的供需信息对于市场成员的引导作用。建立日前市场的双层竞价优化模型，采用强化学习的方法，通过市场中有无关键供求信息披露对于发电商报价预期的影响，推演模拟不同信息披露程度下发电商报价行为，然后从策略演化过程、策略偏离度以及策略收敛速度3个角度进行信息披露程度对市场成员交易行为影响的定量分析，验证市场供需信息的发布程度对于市场成员的引导作用，最后基于推演结果进行总结，并对我国信息披露的建设提出建议与思考。     

苏通GIL运输专用机具动力电池类型探讨

GIL运输专用机具是为安全、可靠、高效地完成苏通GIL综合管廊工程GIL单元的运输任务而研制的专用机具,其中动力电池系统设计是整机设计的重点之一。通过对各种常见动力电池优缺点的分析,并结合苏通GIL运输专用机具对动力电池的需求分析,确定了动力电池系统的技术路线,为苏通GIL运输专用机具的研制提供了坚实的基础。     

某高校既有建筑室内人员相关VOCs目标污染物的实测分析

为研究高校既有建筑室内人群散发对室内VOCs的影响，对高校不同人群样本的教室及会议室两类典型人群密集房间，共82个人群样本对象进行了VOCs采样分析，得到不同实际场景下的人员相关的VOCs浓度水平，并对其潜在的影响因素进行分析。结果表明，共确认了29种与室内人员相关的高检出率且较高浓度值的物质，包括芳香族化合物9种，烷烯烃类9种，酮类和醛类8种，醇酯类以及卤化物3种，并得到主要VOCs物质的浓度水平和I/O比。对影响因素的统计分析表明，室内人员密度、季节和房间类型对不同VOCs物质存在显著性影响，其中季节性因素对目标VOCs污染物影响最为广泛，其次是房间类型与室内人员密度。该研究可为进一步了解人员密集室内VOCs污染现状及控制策略提供一定的科学参考。     

Effect of Biochar as Reductant on Magnetizing-roasting Behavior of Pyrite Cinder

The effect of biochar substituted for anthracite as reductant on magnetizing-roasting pyrite cinder was investigated.The key of magnetizing-roasting is the gasification reaction between reductants and CO2.Since biochar could react with CO2 more rapidly at lower temperature,the reactivity of biochar is better than that of anthracite.The gasification of biochar could produce reducing condition ofφCO/(φCO+φCO2)about 10%-20% between 700-800 ℃,which is in accord with the atmosphere and temperature of Fe2O3 reduction.So it is beneficial to the reduction of iron mineral of pyrite cinder.Compared with anthracite,biochar could decrease the roasting temperature from825 to 750 ℃ and roasting time from 20 to 15min,which shows that a better effect of magnetization could be obtained in the condition of lower temperature and shorter time.Using biochar as reductant,iron concentrate extracted from pyrite cinder as about 64%iron grade could be produced,and the recovery is over 90% under the condition of above 90% grinding particle less than 0.045 mm and magnetic intensity of 0.124-0.194 T.     

马钢张庄矿高压辊磨机装配工艺研究

针对马钢张庄矿高压辊磨机辊套疲劳断裂严重、对辊精度不能满足生产要求等问题，马钢重机公司根据张庄矿实际生产要求对对辊进行国产化，国产化内容包括辊轴、辊套等零部件的新制以及装配工艺攻关，通过技术研发同时结合实际生产经验，成功对高压辊磨机辊套与辊轴以及辊轴与轴承进行装配，完成了张庄矿高压辊磨机整对对辊的国产化，为该型设备后续生产及优化提供了理论和实践参考依据。     

石墨烯热电器件栅控特性研究

为了获得一种稳定可控的能源，提出一种栅控石墨烯热电器件。通过对石墨烯通道的载流子输运机理的分析，获得了温度和栅压对通道电阻的影响。依据半经典Mott公式推导了石墨烯塞贝克系数的表达式，同时给出了石墨烯的电导率和热导率模型。最后通过有限元分析(FEA)建模获得不同栅压条件下的器件温度，当栅极电压V_B=0 V时，石墨烯热电器件热端和冷端温度差为30 K；当V_B=6 V时，最大温差达到50 K；当V_B=30 V时，最小温差只有10 K。结果表明，栅压对热电器件的性能有明显的调控性。该研究可为石墨烯热电器件的设计提供理论参考。     

氧气底吹熔炼氧枪浅析

系统地论述了氧气底吹熔炼氧枪的结构、工作原理、设计计算方法、材质及蚀损机理．指出了延长氧枪使用寿命的措施。     

高温高盐高含水油藏提高水驱采收率配套技术

针对江汉油区高温高盐高含水油藏的储层条件,应用国内外油藏精细描述、油藏工程最新理论与技术,提出了高含水油田合理钻加密井、完善注采井网、水平井挖潜、不稳定注水及高温高盐油藏采油工艺配套技术措施,形成了一套适应高温高盐高含水油藏提高水驱采收率的配套技术。